CobaltMaghrebV1, Main, Exploration, bibRecord, 000080

Lpg0393 of Legionella pneumophila Is a Guanine-Nucleotide Exchange Factor for Rab5, Rab21 and Rab22

Identifieur interne : 000080 ( Main/Exploration ); précédent : 000079; suivant : 000081

Lpg0393 of Legionella pneumophila Is a Guanine-Nucleotide Exchange Factor for Rab5, Rab21 and Rab22

Auteurs : Young-Sik Sohn [Corée du Sud] ; Ho-Chul Shin [Corée du Sud] ; Wei Sun Park [Corée du Sud] ; Jianning Ge [États-Unis] ; Chan-Hee Kim [Corée du Sud] ; Bok Luel Lee [Corée du Sud] ; Won Do Heo [Corée du Sud] ; Jae U. Jung [États-Unis] ; Daniel John Rigden [Royaume-Uni] ; Byung-Ha Oh [Corée du Sud]

Source :

PLoS ONE [ 1932-6203 ] ; 2015.

RBID : PMC:4379102

Abstract

Legionella pneumophila, a human intracellular pathogen, encodes about 290 effector proteins that are translocated into host cells through a secretion machinery. Some of these proteins have been shown to manipulate or subvert cellular processes during infection, but functional roles of a majority of them remain unknown. Lpg0393 is a newly identified Legionella effector classified as a hypothetical protein. Through X-ray crystallographic analysis, we show that Lpg0393 contains a Vps9-like domain, which is structurally most similar to the catalytic core of human Rabex-5 that activates the endosomal Rab proteins Rab5, Rab21 and Rab22. Consistently, Lpg0393 exhibited a guanine-nucleotide exchange factor activity toward the endosomal Rabs. This work identifies the first example of a bacterial guanine-nucleotide exchange factor that is active towards the Rab5 sub-cluster members, implying that the activation of these Rab proteins might be advantageous for the intracellular survival of Legionella.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379102

DOI: 10.1371/journal.pone.0118683
PubMed: 25821953
PubMed Central: 4379102

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p><italic>Legionella pneumophila</italic>
, a human intracellular pathogen, encodes about 290 effector proteins that are translocated into host cells through a secretion machinery. Some of these proteins have been shown to manipulate or subvert cellular processes during infection, but functional roles of a majority of them remain unknown. Lpg0393 is a newly identified <italic>Legionella</italic>
 effector classified as a hypothetical protein. Through X-ray crystallographic analysis, we show that Lpg0393 contains a Vps9-like domain, which is structurally most similar to the catalytic core of human Rabex-5 that activates the endosomal Rab proteins Rab5, Rab21 and Rab22. Consistently, Lpg0393 exhibited a guanine-nucleotide exchange factor activity toward the endosomal Rabs. This work identifies the first example of a bacterial guanine-nucleotide exchange factor that is active towards the Rab5 sub-cluster members, implying that the activation of these Rab proteins might be advantageous for the intracellular survival of <italic>Legionella</italic>
.</p>
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<author><name sortKey="Pypaert, M" uniqKey="Pypaert M">M Pypaert</name>
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</author>
</analytic>
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</author>
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</author>
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</author>
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</author>
<author><name sortKey="Wong, Sk" uniqKey="Wong S">SK Wong</name>
</author>
<author><name sortKey="Isberg, Rr" uniqKey="Isberg R">RR Isberg</name>
</author>
</analytic>
</biblStruct>
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</author>
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<author><name sortKey="Shuman, Ha" uniqKey="Shuman H">HA Shuman</name>
</author>
</analytic>
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</author>
</analytic>
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</author>
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</author>
<author><name sortKey="Ingmundson, A" uniqKey="Ingmundson A">A Ingmundson</name>
</author>
<author><name sortKey="Toomre, Dk" uniqKey="Toomre D">DK Toomre</name>
</author>
<author><name sortKey="Lambright, Dg" uniqKey="Lambright D">DG Lambright</name>
</author>
</analytic>
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</author>
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</author>
<author><name sortKey="Blumer, J" uniqKey="Blumer J">J Blumer</name>
</author>
<author><name sortKey="Blankenfeldt, W" uniqKey="Blankenfeldt W">W Blankenfeldt</name>
</author>
<author><name sortKey="Goody, Rs" uniqKey="Goody R">RS Goody</name>
</author>
</analytic>
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</author>
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</author>
<author><name sortKey="Lambright, Dg" uniqKey="Lambright D">DG Lambright</name>
</author>
<author><name sortKey="Roy, Cr" uniqKey="Roy C">CR Roy</name>
</author>
</analytic>
</biblStruct>
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</author>
<author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name>
</author>
<author><name sortKey="Arasaki, K" uniqKey="Arasaki K">K Arasaki</name>
</author>
<author><name sortKey="Mcdonough, J" uniqKey="Mcdonough J">J McDonough</name>
</author>
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</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tan, Y" uniqKey="Tan Y">Y Tan</name>
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</author>
</analytic>
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<author><name sortKey="Cichy, Al" uniqKey="Cichy A">AL Cichy</name>
</author>
<author><name sortKey="Goody, Rs" uniqKey="Goody R">RS Goody</name>
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</author>
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</author>
<author><name sortKey="Mohammadi, S" uniqKey="Mohammadi S">S Mohammadi</name>
</author>
<author><name sortKey="Jarnik, M" uniqKey="Jarnik M">M Jarnik</name>
</author>
<author><name sortKey="Machner, Mp" uniqKey="Machner M">MP Machner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tan, Y" uniqKey="Tan Y">Y Tan</name>
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<author><name sortKey="Luo, Zq" uniqKey="Luo Z">ZQ Luo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ku, B" uniqKey="Ku B">B Ku</name>
</author>
<author><name sortKey="Lee, Kh" uniqKey="Lee K">KH Lee</name>
</author>
<author><name sortKey="Park, Ws" uniqKey="Park W">WS Park</name>
</author>
<author><name sortKey="Yang, Cs" uniqKey="Yang C">CS Yang</name>
</author>
<author><name sortKey="Ge, J" uniqKey="Ge J">J Ge</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gaspar, Ah" uniqKey="Gaspar A">AH Gaspar</name>
</author>
<author><name sortKey="Machner, Mp" uniqKey="Machner M">MP Machner</name>
</author>
</analytic>
</biblStruct>
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</author>
<author><name sortKey="Finsel, I" uniqKey="Finsel I">I Finsel</name>
</author>
<author><name sortKey="Otto, A" uniqKey="Otto A">A Otto</name>
</author>
<author><name sortKey="Pfaffinger, G" uniqKey="Pfaffinger G">G Pfaffinger</name>
</author>
<author><name sortKey="Rothmeier, E" uniqKey="Rothmeier E">E Rothmeier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lifshitz, Z" uniqKey="Lifshitz Z">Z Lifshitz</name>
</author>
<author><name sortKey="Burstein, D" uniqKey="Burstein D">D Burstein</name>
</author>
<author><name sortKey="Peeri, M" uniqKey="Peeri M">M Peeri</name>
</author>
<author><name sortKey="Zusman, T" uniqKey="Zusman T">T Zusman</name>
</author>
<author><name sortKey="Schwartz, K" uniqKey="Schwartz K">K Schwartz</name>
</author>
</analytic>
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</author>
</analytic>
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<biblStruct><analytic><author><name sortKey="Soding, J" uniqKey="Soding J">J Soding</name>
</author>
<author><name sortKey="Biegert, A" uniqKey="Biegert A">A Biegert</name>
</author>
<author><name sortKey="Lupas, An" uniqKey="Lupas A">AN Lupas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Delprato, A" uniqKey="Delprato A">A Delprato</name>
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<author><name sortKey="Lambright, Dg" uniqKey="Lambright D">DG Lambright</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Uejima, T" uniqKey="Uejima T">T Uejima</name>
</author>
<author><name sortKey="Ihara, K" uniqKey="Ihara K">K Ihara</name>
</author>
<author><name sortKey="Goh, T" uniqKey="Goh T">T Goh</name>
</author>
<author><name sortKey="Ito, E" uniqKey="Ito E">E Ito</name>
</author>
<author><name sortKey="Sunada, M" uniqKey="Sunada M">M Sunada</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Holm, L" uniqKey="Holm L">L Holm</name>
</author>
<author><name sortKey="Rosenstrom, P" uniqKey="Rosenstrom P">P Rosenstrom</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Delprato, A" uniqKey="Delprato A">A Delprato</name>
</author>
<author><name sortKey="Merithew, E" uniqKey="Merithew E">E Merithew</name>
</author>
<author><name sortKey="Lambright, Dg" uniqKey="Lambright D">DG Lambright</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Itzen, A" uniqKey="Itzen A">A Itzen</name>
</author>
<author><name sortKey="Rak, A" uniqKey="Rak A">A Rak</name>
</author>
<author><name sortKey="Goody, Rs" uniqKey="Goody R">RS Goody</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Esters, H" uniqKey="Esters H">H Esters</name>
</author>
<author><name sortKey="Alexandrov, K" uniqKey="Alexandrov K">K Alexandrov</name>
</author>
<author><name sortKey="Iakovenko, A" uniqKey="Iakovenko A">A Iakovenko</name>
</author>
<author><name sortKey="Ivanova, T" uniqKey="Ivanova T">T Ivanova</name>
</author>
<author><name sortKey="Thoma, N" uniqKey="Thoma N">N Thoma</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Suh, Hy" uniqKey="Suh H">HY Suh</name>
</author>
<author><name sortKey="Lee, Dw" uniqKey="Lee D">DW Lee</name>
</author>
<author><name sortKey="Lee, Kh" uniqKey="Lee K">KH Lee</name>
</author>
<author><name sortKey="Ku, B" uniqKey="Ku B">B Ku</name>
</author>
<author><name sortKey="Choi, Sj" uniqKey="Choi S">SJ Choi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Galperin, E" uniqKey="Galperin E">E Galperin</name>
</author>
<author><name sortKey="Sorkin, A" uniqKey="Sorkin A">A Sorkin</name>
</author>
</analytic>
</biblStruct>
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</author>
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</biblStruct>
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<author><name sortKey="Zhu, G" uniqKey="Zhu G">G Zhu</name>
</author>
<author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name>
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<author><name sortKey="Liang, Z" uniqKey="Liang Z">Z Liang</name>
</author>
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</author>
</analytic>
</biblStruct>
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</author>
<author><name sortKey="Zahraoui, A" uniqKey="Zahraoui A">A Zahraoui</name>
</author>
<author><name sortKey="Tavitian, A" uniqKey="Tavitian A">A Tavitian</name>
</author>
<author><name sortKey="Saraste, J" uniqKey="Saraste J">J Saraste</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stein, M" uniqKey="Stein M">M Stein</name>
</author>
<author><name sortKey="Pilli, M" uniqKey="Pilli M">M Pilli</name>
</author>
<author><name sortKey="Bernauer, S" uniqKey="Bernauer S">S Bernauer</name>
</author>
<author><name sortKey="Habermann, Bh" uniqKey="Habermann B">BH Habermann</name>
</author>
<author><name sortKey="Zerial, M" uniqKey="Zerial M">M Zerial</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
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</author>
<author><name sortKey="Gaspar, Ah" uniqKey="Gaspar A">AH Gaspar</name>
</author>
<author><name sortKey="Pallara, C" uniqKey="Pallara C">C Pallara</name>
</author>
<author><name sortKey="Rojas, Al" uniqKey="Rojas A">AL Rojas</name>
</author>
<author><name sortKey="Fernandez Recio, J" uniqKey="Fernandez Recio J">J Fernandez-Recio</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Waterhouse, Am" uniqKey="Waterhouse A">AM Waterhouse</name>
</author>
<author><name sortKey="Procter, Jb" uniqKey="Procter J">JB Procter</name>
</author>
<author><name sortKey="Martin, Dm" uniqKey="Martin D">DM Martin</name>
</author>
<author><name sortKey="Clamp, M" uniqKey="Clamp M">M Clamp</name>
</author>
<author><name sortKey="Barton, Gj" uniqKey="Barton G">GJ Barton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Katoh, K" uniqKey="Katoh K">K Katoh</name>
</author>
<author><name sortKey="Standley, Dm" uniqKey="Standley D">DM Standley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shen, A" uniqKey="Shen A">A Shen</name>
</author>
<author><name sortKey="Lupardus, Pj" uniqKey="Lupardus P">PJ Lupardus</name>
</author>
<author><name sortKey="Morell, M" uniqKey="Morell M">M Morell</name>
</author>
<author><name sortKey="Ponder, El" uniqKey="Ponder E">EL Ponder</name>
</author>
<author><name sortKey="Sadaghiani, Am" uniqKey="Sadaghiani A">AM Sadaghiani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Otwinowski, Z" uniqKey="Otwinowski Z">Z Otwinowski</name>
</author>
<author><name sortKey="Minor, W" uniqKey="Minor W">W Minor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Adams, Pd" uniqKey="Adams P">PD Adams</name>
</author>
<author><name sortKey="Mustyakimov, M" uniqKey="Mustyakimov M">M Mustyakimov</name>
</author>
<author><name sortKey="Afonine, Pv" uniqKey="Afonine P">PV Afonine</name>
</author>
<author><name sortKey="Langan, P" uniqKey="Langan P">P Langan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Emsley, P" uniqKey="Emsley P">P Emsley</name>
</author>
<author><name sortKey="Lohkamp, B" uniqKey="Lohkamp B">B Lohkamp</name>
</author>
<author><name sortKey="Scott, Wg" uniqKey="Scott W">WG Scott</name>
</author>
<author><name sortKey="Cowtan, K" uniqKey="Cowtan K">K Cowtan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brunger, At" uniqKey="Brunger A">AT Brunger</name>
</author>
<author><name sortKey="Adams, Pd" uniqKey="Adams P">PD Adams</name>
</author>
<author><name sortKey="Clore, Gm" uniqKey="Clore G">GM Clore</name>
</author>
<author><name sortKey="Delano, Wl" uniqKey="Delano W">WL DeLano</name>
</author>
<author><name sortKey="Gros, P" uniqKey="Gros P">P Gros</name>
</author>
</analytic>
</biblStruct>
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</region>
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</settlement>
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<name sortKey="Shin, Ho Chul" sort="Shin, Ho Chul" uniqKey="Shin H" first="Ho-Chul" last="Shin">Ho-Chul Shin</name>
</country>
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</region>
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Serveur d'exploration sur le cobalt au Maghreb

Lpg0393 of Legionella pneumophila Is a Guanine-Nucleotide Exchange Factor for Rab5, Rab21 and Rab22

Lpg0393 of Legionella pneumophila Is a Guanine-Nucleotide Exchange Factor for Rab5, Rab21 and Rab22

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	Serveur d'exploration sur le cobalt au Maghreb
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